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Sunday, July 19, 2020 | History

4 edition of Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function found in the catalog.

Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function

Herchulez

Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function

Fifth International Conference (Annals of the New York Academy of Sciences)

by Herchulez

  • 75 Want to read
  • 26 Currently reading

Published by Blackwell Publishing Limited .
Written in English

    Subjects:
  • Cellular biology,
  • Molecular biology,
  • Science,
  • Science/Mathematics,
  • Life Sciences - Biochemistry,
  • Life Sciences - Biology - General,
  • Life Sciences - Biology - Molecular Biology,
  • BIOLOGICAL TRANSPORT,
  • Science / Biology,
  • Calcium channels,
  • Congresses,
  • Sodium channels,
  • Sodium cotransport systems

  • The Physical Object
    FormatPaperback
    Number of Pages400
    ID Numbers
    Open LibraryOL8738427M
    ISBN 101573316490
    ISBN 109781573316491

    The sodium-calcium exchanger (often denoted Na+/Ca2+ exchanger, NCX, or exchange protein) is an antiporter membrane protein Sodium-calcium exchanger at the US National Library of Medicine Medical Subject Headings (MeSH) Diagram at Active transport Cardiac action potential Potassium-dependent sodium-calcium exchanger Yu SP, Choi DW (Jun ). Abstract. Regulation of cytosolic Ca2+ and cytosolic Na+ is critical for lymphocyte cation homeostasis and function. To examine the influence of cytosolic Na+ on Ca2+ regulation in human peripheral blood lymphocytes, Ca2+ entry and cytosolic Ca2+ (measured with fura-2) were monitored in cells in which cytosolic Na+ was increased and/or the Na+ gradient was decreased by reduction of external.

    The plasma membrane Ca 2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells and functions to remove calcium (Ca 2+) from the function is vital for regulating the amount of Ca 2+ within all eukaryotic cells. There is a very large transmembrane electrochemical gradient of Ca 2+ driving the entry of the ion into cells, yet it is very important that they maintain low. Sodium- Calcium Exchange and the Plasma Membrane Ca2+ - Atpase in Cell Function: Fifth International Conference, Volume Paperback Books- Buy Sodium- Calcium Exchange and the Plasma Membrane Ca2+ - Atpase in Cell Function: Fifth International Conference, Volume Books online at lowest price with Rating & Reviews, Free Shipping*, COD.

    The plasma membrane Ca2+-ATPase ACA8 is a novel target of Ca2+-dependent CIPK–CBL complexes which tunes the pump activity affecting a stimulus-induced cytosolic We use cookies to enhance your experience on our continuing to use our website, you are agreeing to our use of cookies. Role of Na:Ca exchange and the plasma membrane Ca2+-ATPase in cell function.


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Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function by Herchulez Download PDF EPUB FB2

Calcium is an ambivalent signal: it is essential for the correct functioning of cell life, but may also become dangerous to it. The plasma membrane Ca 2+ ATPase (PMCA) and the plasma membrane Na + /Ca 2+ exchanger (NCX) are the two mechanisms responsible for Ca 2+ extrusion. The NCX has low Ca 2+ affinity but high capacity for Ca 2+ transport, whereas the PMCA has a high Ca 2+ affinity but low Cited by: Andre Herchuelz and Mordecai P.

Blaustein are the authors of Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function: Fifth International Conference, Volumepublished by : $   Abstract. The rat pancreatic β-cell expresses two splice variants of the Na+/Ca 2+ exchanger 1 (NCX1) and six splice variants of the plasma membrane Ca 2+-ATPase (PMCA).In the β-cell, Na + /Ca 2+ exchange displays a high capacity, contributes to both Ca 2+ outflow and influx and participates to the control of insulin release.

Gain of function studies show that overexpression of Cited by:   Abstract. The rat pancreatic β cell expresses six splice variants of the plasma membrane Ca 2+ ATPase (PMCA) and two splice variants of the Na/Ca exchanger 1 (NCX1).

In the β cell, Na/Ca exchange displays a high capacity, contributes to both Ca 2+ outflow and inflow, and participates to the control of insulin release.

Gain-of-function studies show that overexpression of Cited by: 1. The rat pancreatic β-cell expresses 6 splice variants of the Plasma Membrane Ca 2+-ATPase (PMCA) and two splice variants of the Na + /Ca 2+ exchanger 1 (NCX1).

In the β-cell Na + /Ca 2+ exchange displays a high capacity, contributes to both Ca 2+ outflow and influx and participates to the control of insulin release. Gain of function studies show that overexpression of PMCA2 or NCX1 Cited by: 1.

Abstract: Recent progresses concerning the Na/Ca exchanger (NCX) and the plasma membrane Ca 2+ –ATPase (PMCA) in the pancreatic β cell are reviewed. The rat β cell expresses two splice variants of NCX1 and six splice variants of the 4 PMCA isoforms.

At the protein level, the most abundant forms are PMCA2 and PMCA3, providing the first evidence for the presence of these two. The PMCA pump is a minor component of the total protein of the plasma membrane (less than % of it).

Quantitatively, it is overshadowed by the more powerful NCX in excitable tissue like heart; however, even cells in which the NCX predominates, the PMCA pump is likely to be the fine tuner of cytosolic Ca 2+, as it can operate in a concentration range in which the low affinity NCX is.

Introduction. Cytosolic Ca 2+ regulates several cellular processes and its concentration is, in turn, finely regulated by various channels, pumps and exchangers. The Na/Ca exchanger (NCX) and the plasma membrane Ca 2+-ATPase (PMCA) pump are two concurrent mechanisms for Ca 2+ extrusion from the cell (Carafoli, ; Blaustein & Lederer, ; Philipson & Nicoll, ; Strehler & Treiman,   The plasma membrane (PM) Na 2+ /Ca 2+ exchanger (NCX) is one of the critical mechanisms involved in Ca 2+ homeostasis and the regulation of Ca 2+ signaling in most cells.

The PM NCX was discovered in mammalian cardiac muscle and squid neurons. This chapter shows a critical aspect of the exchanger's function. Roome C.J., Empson R.M. () The Contribution of the Sodium-Calcium Exchanger (NCX) and Plasma Membrane Ca 2+ ATPase (PMCA) to Cerebellar Synapse Function. In: Annunziato L.

(eds) Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications. Advances in Experimental Medicine and Biology, vol Springer, Boston, MA. Introduction. Cytosolic Ca 2+ regulates several cellular processes and its concentration is, in turn, finely regulated by various channels, pumps and exchangers.

The Na/Ca exchanger (NCX) and the plasma membrane Ca 2+ ‐ATPase (PMCA) pump are two concurrent mechanisms for Ca 2+ extrusion from the cell (Carafoli, ; Blaustein & Lederer, ; Philipson & Nicoll, ; Strehler & Treiman.

Julius Nitsche et al. demonstrate that binding of two calmodulin molecules displaces the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8 to. Members of both the sodium/calcium exchangers (NCXs) and the plasma membrane calcium ATPases (PMCAs) are expressed in the intestine, 20,21 although it appears that the former function primarily in the reabsorption of calcium by the kidney.

– These proteins likely mediate the extrusion of calcium from the enterocyte (see Figure ). Request PDF | Na+/Ca2+ Exchange and the Plasma Membrane Ca2+-ATPase in β-Cell Function and Diabetes | The rat pancreatic β-cell expresses two splice variants of the Na+/Ca2+ exchanger 1 (NCX1.

In this video we look at the mechanisms of calcium extrusion from cells, namely the PMCA (Plasma membrane associated calcium ATPase) and the Sodium Calcium Exchanger (NCX). Role of Na/Ca exchange and the plasma membrane Ca2+-ATPase in beta cell function and death.

par Herchuelz, André ;Kamagate, Adama ;Ximenes, Helena ;Van Eylen, Françoise Référence Annals of the New York Academy of Sciences,page (). The Plasma Membrane Ca2+ ATPase and the Plasma Membrane Sodium Calcium Exchanger Cooperate in the Regulation of Cell Calcium.

Brini, li, E. Visualization of Ca2+ Signaling During Embryonic Skeletal Muscle Formation in Vertebrates. Gleichmann, M.P.

Mattson, in Encyclopedia of Neuroscience, Calcium ATPases and Sodium Calcium Exchangers. Plasma membrane Ca 2+ ATPases (PMCA 1–4) pump Ca 2+ out of the cytoplasm into the extracellular space at the expense of ATP.

In addition, sodium calcium exchangers (NCX 1–3) use the Na + gradient to extrude Ca 2+ from the cytosol to the extracellular space by in. The rat pancreatic β-cell expresses two splice variants of the Na+/Ca2+ exchanger 1 (NCX1) and six splice variants of the plasma membrane Ca2+-ATPase (PMCA).

In the β-cell, Na +/Ca2+ exchange displays a high capacity, contributes to both Ca2+ outflow. The sodium-calcium exchanger (often denoted Na + /Ca 2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells.

It uses the energy that is stored in the electrochemical gradient of sodium (Na +) by allowing Na + to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca 2+). The plasma membrane Ca²+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium.

Brini M(1), Carafoli E. Author information: (1)Department of Biological Chemistry, University of Padova, Viale G. Colombo 3, Padova, Italy. @Role of Na/Ca exchange and the plasma membrane Ca2+-ATPase in cell function. Conference on Na/Ca exchange. By D Noble and A Herchuelz.

Cite. Cell Membrane, Sodium-Calcium Exchanger, Signal Transduction.Get this from a library! Sodium-calcium exchange and the plasma membrane Ca2+-ATPase in cell function: fifth international conference.

[Andre Herchuelz; New York Academy of Sciences.;].